how long does it take cbd to work

For any chemical agent you take, it must have undergone a very long process to show its effects. Many chemical processes must have occurred, and there is no single and straight answer to such procedures or questions. Instead, it is more scientific to explain all the possible critical players to justify the subject at hand.

Considering that CBD has been studied along with many derivatives, and many types of research are still going on, researchers have different opinions about it. But whatever will be discussed in this article is based on the amicable agreement of different views.

We will discuss here all that is necessary for CBD to work, and this is based on current . The receptors, as well as the route of administration, play a functional role, and all will be pen down to give the reader a good background on how long does it take for CBD oil to work for pain.

How Does CBD Interact With The Body?

Interaction between this substance and the whole body, mainly the brain, is a complicated process and still requires some researches. There is a lot to contribute regarding the question of how long does it take for CBD oil to work.

Once it enters the body, it interacts with lots of proteins within the body and the central nervous system. These reactions take place mainly in the endocannabinoid system, and they majorly affect the receptors of the CBD. The chemical agent has two receptors, the CB1 and the CB2. In contrast to THC, it does not bind to the receptors but rather alter a process that leads to the activation or inhibition of these receptors.

On the introduction of the cannabidiol to the endocannabinoid, the absorption of this in-born cannabinoid that modulates pain is inhibited. In essence, the effect on the CB1 and CB2 is not direct; all it does is increases the strength of the two most prominent natural endocannabinoids in the body. The two most prevalent cannabinoids in the body that increase in strength are 2-arachnidonoglycerol and anandamide.

Also, researches have shown that in the bid of CBD oil to reduce inflammation and chronic pain, it aimed the receptor of alpha-3 glycine. This is one of the best ways to reduce pain, especially in the spine.

Another important thing is that it also interacts with some receptors that are not related to endocannabinoids such as the serotonin receptors 5-HT1A and the vanilloid receptors like the TRPV1. The popular anti-inflammatory action and the ability to relieve pain is majorly related to these last reactions.

There is one more thing we would like to mention. How long does it take for CBD oil to work for anxiety? Well, it depends. For some people, it might be two to three hours, while others have to wait for days or weeks.

The Method Of Consumption Matters 

How long does it take for CBD to take effect? This is mostly dependent on the consumption procedure. You can take it via various means, and each has its specific effect on the onset of action and the duration of the action.


This is the most common way of taking this substance, and it involves the administration of this substance directly into the mouth. The primary downside of the method is that it undergoes many processes before reaching the bloodstream for proper action. It has to pass through the liver where it will be broken down.

It can undergo the first-pass metabolism in which an enzyme called cytochrome P450 will act on it and decrease the ultimate concentration that will finally reach the bloodstream for action. For the fast and emergency purposes, this method is not the best as it has some form of delay. Likewise, it is not convenient for an individual that is not conscious.


Another method of consumption is to place it under the tongue before swallowing. The mucous membrane is present under the tongue, which absorbs the CBD. All the processes that bring about a delay in the ingestion are bypassed.


Is performed by vaping the vaporized form. Within three minutes, the effect produced will be felt as it goes directly to the bloodstream. It is probably the fastest means to have the effect of this substance.


Topical is typically the application of CBD oil on the localized surface of the area. This method is mainly carried out on the skin to react with the receptors present in the skin. The procedure is perfect to handle chronic pain, and when there is a targeted area. Since we are here, how long does it take for CBD oil to work for joint pain? The answer is 15 to 45 minutes if you apply it to the skin.

Other Factors

There are a few other factors that have a tremendous effect on the onset and duration of action of CBD oil.

Body Weight 

As an individual variation, the mass of an individual affects how long it takes for CBD oil to take its effect because it is stored in the fat cells. It also has an impact on how long the substance remains in the body.


The breaking down of the substance will determine how it will take for active metabolites to start acting. It also affects how long the substances will remain in the body. The metabolism plays a role in the time taken for CBD to work.

Frequency of Use

The rate in which you are exposed to this substance is also a factor to consider. Those who are frequently exposed tend to feel the impact faster than others.

CBD Dosage 

How long it takes to feel the effect is also dependent on the dose administered. The more the treatment, the more the tendency to feel the result faster.


In essence, the time taken for the effect of the CBD to be felt cannot be determined using a single measure. It depends on many factors, as discussed in this article. It is recommended that before anyone ventures into taking this, such factors should be weighed, and the most suitable for the individual should be taken. You should also be sure of the authenticity of the research institute that presents the claimed facts.